United States securities and exchange commission logo November 10, 2021 Joshua T. Brumm President and Chief Executive Officer Dyne Therapeutics, Inc. 830 Winter Street Waltham, Massachusetts 02451 Re: Dyne Therapeutics, Inc. Registration Statement on Form S-3 Filed November 4, 2021 File No. 333-260755 Dear Mr. Brumm: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Michael Davis at 202-551-4385 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Stuart M. Falber, Esq.