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                               September 9, 2020

       Joshua T. Brumm
       President and Chief Executive Officer
       Dyne Therapeutics, Inc.
       830 Winter Street
       Waltham, MA 02451

                                                        Re: Dyne Therapeutics,
Statement on Form S-1
                                                            Filed August 25,
                                                            File No. 333-248414

       Dear Mr. Brumm:

              We have reviewed your registration statement and have the
following comment. In our
       comment we may ask you to provide us with information so we may better
understand your

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comment applies to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this comment, we may have additional comments.

       Registration Statement on Form S-1 filed August 25, 2020

       Business, page 122

   1.                                                   We note your response
to our prior comment 5 and your continued use of "durable,
functional benefit across multiple indications." Please revise your
                                                        characterization of the
preclinical models to discuss the data from the trial, rather than
                                                        drawing conclusions
from the results.
               We remind you that the company and its management are
responsible for the accuracy
       and adequacy of their disclosures, notwithstanding any review, comments,
action or absence of
       action by the staff.
 Joshua T. Brumm
Dyne Therapeutics, Inc.
September 9, 2020
Page 2

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration

       Please contact Laura Crotty at (202) 551-7614 or Jeff Gabor at (202)
551-2544 with any

FirstName LastNameJoshua T. Brumm
                                                           Division of
Corporation Finance
Comapany NameDyne Therapeutics, Inc.
                                                           Office of Life
September 9, 2020 Page 2
cc:       Stuart M. Falber, Esq.
FirstName LastName